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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Translation potential of current preclinical techniques for gene therapy of neurological diseases in clinic. A critical review.
 Žideková, Paulína ; Novák, Ondřej (advisor) ; Jendelová, Pavla (referee)
Research in the field of gene therapy has potential to become a revolutionary way to the existing treatment for a wide spectrum of neurological diseases. To treat these disorders causally, by specific substituting, deleting, silencing or editing faulty genes could be a privilege of gene therapy. The concept of translational medicine is to facilitate the transfer of working principles in preclinical research into treatment in humans. Its key issue is to overcome limitations associated with the gap between the tremendous variety molecular biology tools of preclinical research and the lack of simple corresponding options in humans. Clinical implementation of most of the preclinical approaches is still considered to be limited. The main focus of this thesis is to summarize latest advancements of molecular and genetic engineering tools that themselves or in combination have the potential to promote most preclinical gene therapy of neurological diseases to clinical use. Based on that, this study aims to suggest perspective methods of treatment for selected neurological diseases.
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Dysfunctions of interneurons in schizophrenia
 Hrůzová, Karolína ; Stuchlík, Aleš (advisor) ; Weissová, Kamila (referee)
Schizophrenia is a serious neuropsychiatric disorder characterised by abnormal behaviours, perception and thoughts. It is a neurodevelopmental disease of two types of factors - genetic predispositions and environmental factors. The exact cause of schizophrenia remains, however, elusive. Interneurons are types of neurons, mostly exerting inhibitory action and their dysfunctions are associated with pathogenesis of schizophrenia. They are essential in the generation of neuronal oscillations, which play an important role in cognitive functions. Disruption of these oscillations (especially gamma band) could be paralleled by negative, positive or cognitive symptoms of schizophrenia. These interactions could be possible discerned with an innovative technique called optogenetics. Optogenetics is a combination of genetic and optical approaches to controlling activity of specific targeted neurons. With this method we can study animal models of schizophrenia with great insight, which could give us an explanation of abnormalities in behaviour caused by neuronal disruption. Keywords: schizophrenia; interneurons; animal models; neuronal oscillations; optogenetics
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